Annotated Regenerative Medicine Articles

A comparison of human bone marrow-derived mesenchymal stem cells and human umbilical cord-derived mesenchymal stromal cells for cartilage tissue engineering.

  • In this study, the researchers conclude that hUCMSCs may be a desirable option for use as a mesenchymal cell source for fibrocartilage tissue engineering, based on abundant type I collagen and aggrecan production of hUCMSCs in a 3D matrix, although further investigation of signals that best promote type II collagen production of hUCMSCs is warranted for hyaline cartilage engineering.
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  • Limin Wang, Ivy Tran, Kiran Seshareddy, Mark L. Weiss, and Michael S. Detamore

Immune Characterization of Mesenchymal Stem Cells in Human Umbilical cord, Wharton’s jelly, and derived cartilage cells

  • In this study, the researchers examine Mesenchymal stem cells derived from human umbilical cord Wharton’s jelly (hWJMSCs) and became prospective seed cell candidate for tissue engineering and cell-based therapy because of its variety source, easy procurement, robust proliferation, and high purity compared with bone marrow- and adipose-derived MSCs.
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  • Shuyun Liu, Mei Yuan, Kedong Hou, Li Zhang, Xifu Zheng, Bin Zhao, Xiang Sui, Wenjing Xu, Shibi Lu, Quanyi Guo

Stem Cell Application for Osteoarthritis in the Knee Joint: A Mini Review

  • The aim of this review is to outline the latest advances in stem cell therapy for knee osteoarthritis as well as highlight some of the advantages of stem cell therapy over traditional approaches aimed at restoration of cartilage function in the knee.
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  • Kristin Uth and Dimitar Trifonov

Current Perspectives in Stem Cell Research for Knee Cartilage Repair

  • This review draws attention to the different perspectives on stem cell therapy for repairing damaged cartilage in the knees. It also provides adequate research about the issue with cartilage repair and the role of stem cell therapy during recovery.
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  • Patrick Orth, Ana Rey-Rico, Jagadeesh K Venkatesan, Henning Madry, and Magali Cucchiarini

Clinical Efficacy and Safety of Mesenchymal Stem Cell Transplantation for Osteoarthritis Treatment: A Meta-analysis

  • In this study, the researchers examine the therapeutic efficacy and safety of mesenchymal stem cells (MSCs) for knee osteoarthritis (OA) therapy. It provides significant information about the effectiveness of stem cell therapy for knee osteoarthritis.
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  • Ma Yubo, Li Yanyan, Li Li, Sun Tao, Lin Bo, and Chen Lin


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Advances and Prospects in Stem Cells for Cartilage Regeneration

  • This review examines emerging trends on using stem cells in cartilage tissue repair and regenerative medicine. It focuses on the characterization of cartilage stem cells, the chondrogenic differentiation of stem cells, and the various strategies, approaches, and clinical studies.
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  • Mingjie Wang, Zhiguo Yuan, Ning Ma, Chunxiang Hao, Weimin Guo, Gengyi Zou, Yu Zhang, Mingxue Chen, Shuang Gao, Jiang Peng, Aiyuan Wang, Yu Wang, Xiang Sui, Wenjing Xu, Shibi Lu, Shuyun Liu, and Quanyi Guo

Cartilage Repair by Mesenchymal Stem Cells: Clinical Trial Update and Perspectives

  • This review summarizes recently reported MSC-based clinical trials and discusses new research directions with particular focus on the potential application of MSC-derived extracellular vehicles, miRNAs and advanced gene editing techniques.
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  • Wayne Yuk-wai Lee and Bin Wang

Mesenchymal Stem Cell Therapy in the Treatment of Hip Osteoarthritis

  • This study was performed to investigate the safety and efficacy of the intra-articular infusion of ex vivo expanded autologous bone marrow-derived mesenchymal stem cells (BM-MSC) to a cohort of patients with articular cartilage defects in the hip.
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  • Rodrigo Mardones, Claudio M. Jofré, L. Tobar, José J. Minguell

Regenerative Medicine boosts the body's ability to heal itself naturally. Treatment with regenerative medicine can create living tissue in the body that has been damaged from disease or degeneration.

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